Mice with an Increased Glucocorticoid Receptor Gene Dosage Show Enhanced Resistance to Stress and Endotoxic Shock

Targeted mutagenesis of the glucocorticoid receptor has revealed an essential function for survival and the regulation of multiple physiological processes. To investigate the effects of an increased gene dosage of the receptor, we have generated transgenic mice carrying two additional copies of the...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Reichardt, Holger M., Umland, Thorsten, Bauer, Anton, Kretz, Oliver, Schütz, Günther
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2000
Sujets:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11073999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.9009-9017.2000
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