CUL-4A Is Critical for Early Embryonic Development

Ubiquitin-mediated degradation targets cell cycle regulators for proteolysis. Much of the ubiquitin pathway's substrate specificity is conferred by E3 ubiquitin ligases, and cullins are core components of some E3s. CUL-4A encodes one of six mammalian cullins and is amplified and/or overexpresse...

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Detalhes bibliográficos
Main Authors: Li, Binghui, Ruiz, Joseph C., Chun, Kristin T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139768/
https://ncbi.nlm.nih.gov/pubmed/12077329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.14.4997-5005.2002
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