Proteasome-Mediated Degradation of the Coactivator p300 Impairs Cardiac Transcription

The transcription of tissue-specific genes is controlled by regulatory factors and cofactors and is suppressed in cardiac cells by the antineoplastic agent doxorubicin. Here we show that exposure of cultured cardiomyocytes to doxorubicin resulted in the rapid depletion of transcripts for MEF2C, dHAN...

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Podrobná bibliografie

Vydáno v:	Mol Cell Biol
Hlavní autoři:	Poizat, Coralie, Sartorelli, Vittorio, Chung, Gene, Kloner, Robert A., Kedes, Larry
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2000
Témata:	Transcriptional Regulation
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86467/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11073966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.8643-8654.2000
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