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Proteasome-Mediated Degradation of the Coactivator p300 Impairs Cardiac Transcription

The transcription of tissue-specific genes is controlled by regulatory factors and cofactors and is suppressed in cardiac cells by the antineoplastic agent doxorubicin. Here we show that exposure of cultured cardiomyocytes to doxorubicin resulted in the rapid depletion of transcripts for MEF2C, dHAN...

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Bibliografski detalji
Glavni autori: Poizat, Coralie, Sartorelli, Vittorio, Chung, Gene, Kloner, Robert A., Kedes, Larry
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC86467/
https://ncbi.nlm.nih.gov/pubmed/11073966
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