Proteasome-Mediated Degradation of the Coactivator p300 Impairs Cardiac Transcription

The transcription of tissue-specific genes is controlled by regulatory factors and cofactors and is suppressed in cardiac cells by the antineoplastic agent doxorubicin. Here we show that exposure of cultured cardiomyocytes to doxorubicin resulted in the rapid depletion of transcripts for MEF2C, dHAN...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Poizat, Coralie, Sartorelli, Vittorio, Chung, Gene, Kloner, Robert A., Kedes, Larry
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86467/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11073966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.23.8643-8654.2000
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