The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site

Splicing of the K-SAM alternative exon of the fibroblast growth factor receptor 2 gene is heavily dependent on the U-rich sequence IAS1 lying immediately downstream from its 5′ splice site. We show that IAS1 can activate the use of several heterologous 5′ splice sites in vitro. Addition of the RNA-b...

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Autores principales: Del Gatto-Konczak, Fabienne, Bourgeois, Cyril F., Le Guiner, Caroline, Kister, Liliane, Gesnel, Marie-Claude, Stévenin, James, Breathnach, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC86103/
https://ncbi.nlm.nih.gov/pubmed/10938105
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