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The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site

Splicing of the K-SAM alternative exon of the fibroblast growth factor receptor 2 gene is heavily dependent on the U-rich sequence IAS1 lying immediately downstream from its 5′ splice site. We show that IAS1 can activate the use of several heterologous 5′ splice sites in vitro. Addition of the RNA-b...

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Wedi'i Gadw mewn:
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Del Gatto-Konczak, Fabienne, Bourgeois, Cyril F., Le Guiner, Caroline, Kister, Liliane, Gesnel, Marie-Claude, Stévenin, James, Breathnach, Richard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2000
Pynciau:
Gene Expression
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86103/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10938105/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.17.6287-6299.2000
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