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Evidence for an Interaction between Ubiquitin-Conjugating Enzymes and the 26S Proteasome

The targeting of proteolytic substrates is accomplished by a family of ubiquitin-conjugating (E2) enzymes and a diverse set of substrate recognition (E3) factors. The ligation of a multiubiquitin chain to a substrate can promote its degradation by the proteasome. However, the mechanism that facilita...

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Detalhes bibliográficos
Main Authors: Tongaonkar, Prasad, Chen, Li, Lambertson, David, Ko, Bom, Madura, Kiran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85887/
https://ncbi.nlm.nih.gov/pubmed/10848595
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