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Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation

The kinase PAK binds tightly to the SH3 domain of its partner PIX via a central proline-rich sequence. A different N-terminal sequence allows αPAK to bind an SH3 domain of the adaptor Nck. The Nck SH3[2] domain interacts equally with an 18-mer PAK-derived peptide and full-length αPAK. Detailed analy...

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Hlavní autoři: Zhao, Zhou-shen, Manser, Edward, Lim, Louis
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC85736/
https://ncbi.nlm.nih.gov/pubmed/10805734
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