A PAK1–PIX–PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT
Given the importance of the Rho GTPase family member Rac1 and the Rac1/Cdc42 effector PAK1 in T-cell activation, we investigated the requirements for their activation by the T-cell receptor (TCR). Rac1 and PAK1 activation required the tyrosine kinases ZAP-70 and Syk, but not the cytoplasmic adaptor...
Zapisane w:
| Wydane w: | EMBO J |
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| Główni autorzy: | , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133476/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157752/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.3.457 |
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