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A PAK1–PIX–PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT
Given the importance of the Rho GTPase family member Rac1 and the Rac1/Cdc42 effector PAK1 in T-cell activation, we investigated the requirements for their activation by the T-cell receptor (TCR). Rac1 and PAK1 activation required the tyrosine kinases ZAP-70 and Syk, but not the cytoplasmic adaptor...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133476/ https://ncbi.nlm.nih.gov/pubmed/11157752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.3.457 |
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