A PAK1–PIX–PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT

Given the importance of the Rho GTPase family member Rac1 and the Rac1/Cdc42 effector PAK1 in T-cell activation, we investigated the requirements for their activation by the T-cell receptor (TCR). Rac1 and PAK1 activation required the tyrosine kinases ZAP-70 and Syk, but not the cytoplasmic adaptor...

Description complète

Détails bibliographiques

Publié dans:	EMBO J
Auteurs principaux:	Ku, Gregory M., Yablonski, Deborah, Manser, Edward, Lim, Louis, Weiss, Arthur
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2001
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133476/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157752/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.3.457
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!