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A PAK1–PIX–PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT

Given the importance of the Rho GTPase family member Rac1 and the Rac1/Cdc42 effector PAK1 in T-cell activation, we investigated the requirements for their activation by the T-cell receptor (TCR). Rac1 and PAK1 activation required the tyrosine kinases ZAP-70 and Syk, but not the cytoplasmic adaptor...

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Udgivet i:EMBO J
Principais autores: Ku, Gregory M., Yablonski, Deborah, Manser, Edward, Lim, Louis, Weiss, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133476/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157752/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.3.457
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