A PAK1–PIX–PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT

Given the importance of the Rho GTPase family member Rac1 and the Rac1/Cdc42 effector PAK1 in T-cell activation, we investigated the requirements for their activation by the T-cell receptor (TCR). Rac1 and PAK1 activation required the tyrosine kinases ZAP-70 and Syk, but not the cytoplasmic adaptor...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ku, Gregory M., Yablonski, Deborah, Manser, Edward, Lim, Louis, Weiss, Arthur
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC133476/
https://ncbi.nlm.nih.gov/pubmed/11157752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.3.457
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky