Interaction between PAK and Nck: a Template for Nck Targets and Role of PAK Autophosphorylation
The kinase PAK binds tightly to the SH3 domain of its partner PIX via a central proline-rich sequence. A different N-terminal sequence allows αPAK to bind an SH3 domain of the adaptor Nck. The Nck SH3[2] domain interacts equally with an 18-mer PAK-derived peptide and full-length αPAK. Detailed analy...
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| Udgivet i: | Mol Cell Biol |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85736/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.11.3906-3917.2000 |
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