Granzyme B Short-Circuits the Need for Caspase 8 Activity during Granule-Mediated Cytotoxic T-Lymphocyte Killing by Directly Cleaving Bid

Cytotoxic T lymphocytes (CTL) can trigger an apoptotic signal through the Fas receptor or by the exocytosis of granzyme B and perforin. Caspase activation is an important component of both pathways. Granzyme B, a serine proteinase contained in granules, has been shown to proteolytically process and...

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Hauptverfasser: Barry, Michele, Heibein, Jeffrey A., Pinkoski, Michael J., Lee, Siow-Fong, Moyer, Richard W., Green, Douglas R., Bleackley, R. Chris
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85698/
https://ncbi.nlm.nih.gov/pubmed/10805722
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