Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax

Cytotoxic T lymphocytes (CTLs) destroy target cells through a mechanism involving the exocytosis of cytolytic granule components including granzyme B (grB) and perforin, which have been shown to induce apoptosis through caspase activation. However, grB has also been linked with caspase-independent d...

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Main Authors: Heibein, Jeffrey A., Goping, Ing Swie, Barry, Michele, Pinkoski, Michael J., Shore, Gordon C., Green, Douglas R., Bleackley, R. Chris
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193181/
https://ncbi.nlm.nih.gov/pubmed/11085742
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