Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins

The pocket domain of pRB is required for pRB to arrest the cell cycle. This domain was originally defined as the region of the protein that is necessary and sufficient for pRB's interaction with adenovirus E1A and simian virus s40 large T antigen. These oncoproteins, and other pRB-binding proteins t...

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הוצא לאור ב:	Mol Cell Biol
Principais autores:	Dick, Frederick A., Sailhamer, Elizabeth, Dyson, Nicholas J.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis 2000
נושאים:	Cell Growth and Development
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85672/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10779361/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.10.3715-3727.2000
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