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Human Papillomavirus Type 16 E7 Oncoprotein Can Induce Abnormal Centrosome Duplication through a Mechanism Independent of Inactivation of Retinoblastoma Protein Family Members

The human papillomavirus type 16 (HPV-16) E7 oncoprotein rapidly induces centrosome duplication errors in primary human cells, thereby increasing the propensity for multipolar mitoses, which can lead to chromosome missegregation and aneuploidy. We analyzed a series of HPV-16 E7 mutants and demonstra...

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Bibliografische gegevens
Hoofdauteurs: Duensing, Stefan, Münger, Karl
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2003
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC254291/
https://ncbi.nlm.nih.gov/pubmed/14581569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.22.12331-12335.2003
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