Human Papillomavirus Type 16 E7 Oncoprotein Can Induce Abnormal Centrosome Duplication through a Mechanism Independent of Inactivation of Retinoblastoma Protein Family Members

The human papillomavirus type 16 (HPV-16) E7 oncoprotein rapidly induces centrosome duplication errors in primary human cells, thereby increasing the propensity for multipolar mitoses, which can lead to chromosome missegregation and aneuploidy. We analyzed a series of HPV-16 E7 mutants and demonstra...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Duensing, Stefan, Münger, Karl
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Transformation and Oncogenesis
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC254291/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14581569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.22.12331-12335.2003
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