Involvement of Myc Activity in a G(1)/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

The retinoblastoma protein (pRb)/E2F pathway regulates commitment of mammalian cells to replicate DNA. On the other hand, mitogen-stimulated cells deprived of E2F activity can still maintain physiologically relevant levels of cyclin E-dependent kinase activity and gradually enter S phase, suggesting...

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Hlavní autoři: Santoni-Rugiu, Eric, Falck, Jacob, Mailand, Niels, Bartek, Jiri, Lukas, Jiri
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC85642/
https://ncbi.nlm.nih.gov/pubmed/10779339
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