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Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability
DNA replication in higher eukaryotes requires activation of a Cdk2 kinase by Cdc25A, a labile phosphatase subject to further destabilization upon genotoxic stress. We describe a distinct, markedly stable form of Cdc25A, which plays a previously unrecognized role in mitosis. Mitotic stabilization of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC131064/ https://ncbi.nlm.nih.gov/pubmed/12411508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf567 |
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