Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

Homologous recombination (HR) is essential for faithful repair of DNA lesions yet must be kept in check, as unrestrained HR may compromise genome integrity and lead to premature aging or cancer. To limit unscheduled HR, cells possess DNA helicases capable of preventing excessive recombination. In th...

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Detalhes bibliográficos
Main Authors: Fugger, Kasper, Mistrik, Martin, Danielsen, Jannie Rendtlew, Dinant, Christoffel, Falck, Jacob, Bartek, Jiri, Lukas, Jiri, Mailand, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742184/
https://ncbi.nlm.nih.gov/pubmed/19736316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200812138
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