CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

The conserved MRE11–RAD50–NBS1 (MRN) complex is an important sensor of DNA double-strand breaks (DSBs) and facilitates DNA repair by homologous recombination (HR) and end joining. Here, we identify NBS1 as a target of cyclin-dependent kinase (CDK) phosphorylation. We show that NBS1 serine 432 phosph...

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Autors principals: Falck, Jacob, Forment, Josep V, Coates, Julia, Mistrik, Martin, Lukas, Jiri, Bartek, Jiri, Jackson, Stephen P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367243/
https://ncbi.nlm.nih.gov/pubmed/22565321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.58
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