DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

A single double-strand break (DSB) induced by HO endonuclease triggers both repair by homologous recombination and activation of the Mec1-dependent DNA damage checkpoint in budding yeast(1–6). Here we report that DNA damage checkpoint activation by a DSB requires the cyclin-dependent kinase CDK1 (Cd...

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Veröffentlicht in:Nature
Hauptverfasser: Ira, Grzegorz, Pellicioli, Achille, Balijja, Alitukiriza, Wang, Xuan, Fiorani, Simona, Carotenuto, Walter, Liberi, Giordano, Bressan, Debra, Wan, Lihong, Hollingsworth, Nancy M., Haber, James E., Foiani, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493751/
https://ncbi.nlm.nih.gov/pubmed/15496928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature02964
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