Srs2 and Sgs1 DNA Helicases Associate with Mre11 in Different Subcomplexes following Checkpoint Activation and CDK1-Mediated Srs2 Phosphorylation

Mutations in the genes encoding the BLM and WRN RecQ DNA helicases and the MRE11-RAD50-NBS1 complex lead to genome instability and cancer predisposition syndromes. The Saccharomyces cerevisiae Sgs1 RecQ helicase and the Mre11 protein, together with the Srs2 DNA helicase, prevent chromosome rearrange...

Full description

Saved in:
Bibliographic Details
Main Authors: Chiolo, Irene, Carotenuto, Walter, Maffioletti, Giulio, Petrini, John H. J., Foiani, Marco, Liberi, Giordano
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Chromosome Structure and Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1156977/
https://ncbi.nlm.nih.gov/pubmed/15964827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5738-5751.2005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items