Srs2 and Sgs1 DNA Helicases Associate with Mre11 in Different Subcomplexes following Checkpoint Activation and CDK1-Mediated Srs2 Phosphorylation

Mutations in the genes encoding the BLM and WRN RecQ DNA helicases and the MRE11-RAD50-NBS1 complex lead to genome instability and cancer predisposition syndromes. The Saccharomyces cerevisiae Sgs1 RecQ helicase and the Mre11 protein, together with the Srs2 DNA helicase, prevent chromosome rearrange...

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Detalhes bibliográficos
Main Authors: Chiolo, Irene, Carotenuto, Walter, Maffioletti, Giulio, Petrini, John H. J., Foiani, Marco, Liberi, Giordano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1156977/
https://ncbi.nlm.nih.gov/pubmed/15964827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5738-5751.2005
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