Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

Werner's syndrome (WS) is a human disease with manifestations resembling premature aging. The gene defective in WS, WRN, encodes a DNA helicase. Here, we describe the generation of mice bearing a mutation that eliminates expression of the C terminus of the helicase domain of the WRN protein. Mu...

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Main Authors: Lombard, David B., Beard, Caroline, Johnson, Brad, Marciniak, Robert A., Dausman, Jessie, Bronson, Roderick, Buhlmann, Janet E., Lipman, Ruth, Curry, Ruth, Sharpe, Arlene, Jaenisch, Rudolf, Guarente, Leonard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC85622/
https://ncbi.nlm.nih.gov/pubmed/10757812
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