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Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

Werner's syndrome (WS) is a human disease with manifestations resembling premature aging. The gene defective in WS, WRN, encodes a DNA helicase. Here, we describe the generation of mice bearing a mutation that eliminates expression of the C terminus of the helicase domain of the WRN protein. Mutant...

Ausführliche Beschreibung

Gespeichert in:
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Lombard, David B., Beard, Caroline, Johnson, Brad, Marciniak, Robert A., Dausman, Jessie, Bronson, Roderick, Buhlmann, Janet E., Lipman, Ruth, Curry, Ruth, Sharpe, Arlene, Jaenisch, Rudolf, Guarente, Leonard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2000
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85622/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10757812/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.9.3286-3291.2000
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