Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex

The ARF tumor suppressor protein stabilizes p53 by antagonizing its negative regulator, Mdm2 (Hdm2 in humans). Both mouse p19(ARF) and human p14(ARF) bind to the central region of Mdm2 (residues 210 to 304), a segment that does not overlap with its N-terminal p53-binding domain, nuclear import or ex...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Weber, Jason D., Kuo, Mei-Ling, Bothner, Brian, DiGiammarino, Enrico L., Kriwacki, Richard W., Roussel, Martine F., Sherr, Charles J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC85460/
https://ncbi.nlm.nih.gov/pubmed/10713175
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares