The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf

The Bcr-Abl tyrosine kinase constitutively activates cytokine signal transduction pathways that stimulate growth and prevent apoptosis in hematopoietic cells. The antiapoptotic action of interleukin-3 (IL-3) has been linked to a signaling pathway which inactivates the proapoptotic protein Bad by pho...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Neshat, Mehran S., Raitano, Arthur B., Wang, Hong-Gang, Reed, John C., Sawyers, Charles L.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2000
Témata:	Cell Growth and Development
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85238/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648603/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.4.1179-1186.2000
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