Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains

The structure of Janus kinases (JAKs) is unique among protein tyrosine kinases in having tandem, nonidentical kinase and pseudokinase domains. Despite its conservation in evolution, however, the function of the pseudokinase domain remains poorly understood. Lack of JAK3 expression results in severe...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Chen, Min, Cheng, Alan, Candotti, Fabio, Zhou, Yong-Jie, Hymel, Anka, Fasth, Anders, Notarangelo, Luigi D., O'Shea, John J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2000
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10629052/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.3.947-956.2000
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