Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains

The structure of Janus kinases (JAKs) is unique among protein tyrosine kinases in having tandem, nonidentical kinase and pseudokinase domains. Despite its conservation in evolution, however, the function of the pseudokinase domain remains poorly understood. Lack of JAK3 expression results in severe...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Chen, Min, Cheng, Alan, Candotti, Fabio, Zhou, Yong-Jie, Hymel, Anka, Fasth, Anders, Notarangelo, Luigi D., O'Shea, John J.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10629052/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.3.947-956.2000
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