Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains

The structure of Janus kinases (JAKs) is unique among protein tyrosine kinases in having tandem, nonidentical kinase and pseudokinase domains. Despite its conservation in evolution, however, the function of the pseudokinase domain remains poorly understood. Lack of JAK3 expression results in severe...

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Bibliografski detalji

Izdano u:	Mol Cell Biol
Glavni autori:	Chen, Min, Cheng, Alan, Candotti, Fabio, Zhou, Yong-Jie, Hymel, Anka, Fasth, Anders, Notarangelo, Luigi D., O'Shea, John J.
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 2000
Teme:	Cell Growth and Development
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10629052/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.3.947-956.2000
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