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Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

In many types of apoptosis, the proapoptotic protein Bax undergoes a change in conformation at the level of the mitochondria. This event always precedes the release of mitochondrial cytochrome c, which, in the cytosol, activates caspases through binding to Apaf-1. The mechanisms by which Bax trigger...

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Bibliografiska uppgifter
Huvudupphovsmän: Eskes, Robert, Desagher, Solange, Antonsson, Bruno, Martinou, Jean-Claude
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC85210/
https://ncbi.nlm.nih.gov/pubmed/10629050
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