BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: role of permeability transition and SH-redox regulation

BAX cooperates with truncated BID (tBID) and Ca(2+) in permeabilizing the outer mitochondrial membrane (OMM) and releasing mitochondrial apoptogenic proteins. The mechanisms of this cooperation are still unclear. Here we show that in isolated brain mitochondria, recombinant BAX readily self-integrat...

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Main Authors: Brustovetsky, Tatiana, Li, Tsyregma, Yang, Youyun, Zhang, Jiang-Ting, Antonsson, Bruno, Brustovetsky, Nickolay
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933961/
https://ncbi.nlm.nih.gov/pubmed/20655869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2010.07.006
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