Sequential Regulation of the Small GTPase Rap1 in Human Platelets

Rap1, a small GTPase of the Ras family, is ubiquitously expressed and particularly abundant in platelets. Previously we have shown that Rap1 is rapidly activated after stimulation of human platelets with α-thrombin. For this activation, a phospholipase C-mediated increase in intracellular calcium is...

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Main Authors: Franke, Barbara, van Triest, Miranda, de Bruijn, Kim M. T., van Willigen, Gijsbert, Nieuwenhuis, H. Karel, Negrier, Claude, Akkerman, Jan-Willem N., Bos, Johannes L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85194/
https://ncbi.nlm.nih.gov/pubmed/10629034
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