Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets.

Physiological concentrations of low-density lipoprotein (LDL) sensitize blood platelets to alpha-thrombin- and collagen-induced secretion, and after prolonged contact trigger secretion independent of other agonists. Here we report that LDL activates the small GTPases Rap1 and Ral but not Ras, as ass...

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Autores principales: Hackeng, C M, Franke, B, Relou, I A, Gorter, G, Bos, J L, van Rijn , H J, Akkerman, J W
Formato: Artigo
Lenguaje:Inglês
Publicado: 2000
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221142/
https://ncbi.nlm.nih.gov/pubmed/10861233
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