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An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo

Many antitumor and antibacterial drugs inhibit DNA topoisomerases by trapping covalent enzyme-DNA cleavage complexes. Formation of cleavage complexes is important for cytotoxicity, but evidence suggests that cleavage complexes themselves are not sufficient to cause cell death. Rather, active cellula...

詳細記述

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書誌詳細
主要な著者: Hong, George, Kreuzer, Kenneth N.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC85141/
https://ncbi.nlm.nih.gov/pubmed/10611238
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