An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo

Many antitumor and antibacterial drugs inhibit DNA topoisomerases by trapping covalent enzyme-DNA cleavage complexes. Formation of cleavage complexes is important for cytotoxicity, but evidence suggests that cleavage complexes themselves are not sufficient to cause cell death. Rather, active cellula...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Hong, George, Kreuzer, Kenneth N.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2000
Assuntos:	DNA Dynamics and Chromosome Structure
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85141/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10611238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.2.594-603.2000
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