Analysis of topoisomerase function in bacterial replication fork movement: Use of DNA microarrays

We used DNA microarrays of the Escherichia coli genome to trace the progression of chromosomal replication forks in synchronized cells. We found that both DNA gyrase and topoisomerase IV (topo IV) promote replication fork progression. When both enzymes were inhibited, the replication fork stopped ra...

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Autori principali: Khodursky, Arkady B., Peter, Brian J., Schmid, Molly B., DeRisi, Joseph, Botstein, David, Brown, Patrick O., Cozzarelli, Nicholas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC16879/
https://ncbi.nlm.nih.gov/pubmed/10944214
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