An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo

Many antitumor and antibacterial drugs inhibit DNA topoisomerases by trapping covalent enzyme-DNA cleavage complexes. Formation of cleavage complexes is important for cytotoxicity, but evidence suggests that cleavage complexes themselves are not sufficient to cause cell death. Rather, active cellula...

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Bibliografski detalji

Izdano u:	Mol Cell Biol
Glavni autori:	Hong, George, Kreuzer, Kenneth N.
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 2000
Teme:	DNA Dynamics and Chromosome Structure
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85141/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10611238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.2.594-603.2000
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