Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue of AML1-Deficient Embryonic Stem Cells by Using a Knock-in Strategy

AML1 is one of the most frequently mutated genes associated with human acute leukemia and encodes the DNA-binding subunit of the heterodimering transcriptional factor complex, core-binding factor (CBF) (or polyoma enhancer binding protein 2 [PEBP2]). A null mutation in either AML1 or its dimerizing...

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Detalhes bibliográficos
Main Authors: Okuda, Tsukasa, Takeda, Kiyoshi, Fujita, Yasuko, Nishimura, Motohiro, Yagyu, Shigeki, Yoshida, Makie, Akira, Shizuo, Downing, James R., Abe, Tatsuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85087/
https://ncbi.nlm.nih.gov/pubmed/10594034
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