AML1/RUNX1 Works as a Negative Regulator of c-Mpl in Hematopoietic Stem Cells

In this study, we analyzed the roles for AML1/RUNX1 in the regulation of the c-mpl promoter. Wild-type AML1 activated the c-mpl promoter through the proximal AML-binding site in luciferase assays using 293T and HeLa cells. In accord with this result, electrophoretic mobility shift assay and chromati...

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Detalhes bibliográficos
Main Authors: Satoh, Yusuke, Matsumura, Itaru, Tanaka, Hirokazu, Ezoe, Sachiko, Fukushima, Kentaro, Tokunaga, Masahiro, Yasumi, Masato, Shibayama, Hirohiko, Mizuki, Masao, Era, Takumi, Okuda, Tsukasa, Kanakura, Yuzuru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662069/
https://ncbi.nlm.nih.gov/pubmed/18687690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804768200
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