BCR-ABL but Not JAK2 V617F Inhibits Erythropoiesis through the Ras Signal by Inducing p21(CIP1/WAF1)

BCR-ABL is a causative tyrosine kinase (TK) of chronic myelogenous leukemia (CML). In CML patients, although myeloid cells are remarkably proliferating, erythroid cells are rather decreased and anemia is commonly observed. This phenotype is quite different from that observed in polycythemia vera (PV...

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Hlavní autoři: Tokunaga, Masahiro, Ezoe, Sachiko, Tanaka, Hirokazu, Satoh, Yusuke, Fukushima, Kentaro, Matsui, Keiko, Shibata, Masaru, Tanimura, Akira, Oritani, Kenji, Matsumura, Itaru, Kanakura, Yuzuru
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951249/
https://ncbi.nlm.nih.gov/pubmed/20663870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118653
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