FIP1L1-PDGFRα Imposes Eosinophil Lineage Commitment on Hematopoietic Stem/Progenitor Cells

Although leukemogenic tyrosine kinases (LTKs) activate a common set of downstream molecules, the phenotypes of leukemia caused by LTKs are rather distinct. Here we report the molecular mechanism underlying the development of hypereosinophilic syndrome/chronic eosinophilic leukemia by FIP1L1-PDGFRα....

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Detalhes bibliográficos
Main Authors: Fukushima, Kentaro, Matsumura, Itaru, Ezoe, Sachiko, Tokunaga, Masahiro, Yasumi, Masato, Satoh, Yusuke, Shibayama, Hirohiko, Tanaka, Hirokazu, Iwama, Atsushi, Kanakura, Yuzuru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658066/
https://ncbi.nlm.nih.gov/pubmed/19147501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807489200
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