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Stabilizing Effects of Interruptions on Trinucleotide Repeat Expansions in Saccharomyces cerevisiae

In most trinucleotide repeat (TNR) diseases, the primary factor determining the likelihood of expansions is the length of the TNR. In some diseases, however, stable alleles contain one to three base pair substitutions that interrupt the TNR tract. The unexpected stability of these alleles compared t...

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Main Authors: Rolfsmeier, Michael L., Lahue, Robert S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2000
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC85072/
https://ncbi.nlm.nih.gov/pubmed/10594019
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