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The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

Farnesyltransferase inhibitors (FTIs) represent a novel class of anticancer drugs that exhibit a remarkable ability to inhibit malignant transformation without toxicity to normal cells. However, the mechanism by which FTIs inhibit tumor growth is not well understood. Here, we demonstrate that FTI-27...

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Udgivet i:Mol Cell Biol
Principais autores: Jiang, Kun, Coppola, Domenico, Crespo, Nichole C., Nicosia, Santo V., Hamilton, Andrew D., Sebti, Said M., Cheng, Jin Q.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85069/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10594016/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.1.139-148.2000
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