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Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

PTEN is a tumor suppressor gene located on chromosome 10q23 that encodes a protein and phospholipid phosphatase. Somatic mutations of PTEN are found in a number of human malignancies, and loss of expression, or mutational inactivation of PTEN, leads to the constitutive activation of protein kinase B...

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Bibliografiske detaljer
Main Authors: Persad, Sujata, Attwell, Sarah, Gray, Virginia, Delcommenne, Marc, Troussard, Armelle, Sanghera, Jasbinder, Dedhar, Shoukat
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16217/
https://ncbi.nlm.nih.gov/pubmed/10716737
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