Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

PTEN is a tumor suppressor gene located on chromosome 10q23 that encodes a protein and phospholipid phosphatase. Somatic mutations of PTEN are found in a number of human malignancies, and loss of expression, or mutational inactivation of PTEN, leads to the constitutive activation of protein kinase B...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Persad, Sujata, Attwell, Sarah, Gray, Virginia, Delcommenne, Marc, Troussard, Armelle, Sanghera, Jasbinder, Dedhar, Shoukat
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16217/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716737/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.060579697
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