The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

Farnesyltransferase inhibitors (FTIs) represent a novel class of anticancer drugs that exhibit a remarkable ability to inhibit malignant transformation without toxicity to normal cells. However, the mechanism by which FTIs inhibit tumor growth is not well understood. Here, we demonstrate that FTI-27...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Jiang, Kun, Coppola, Domenico, Crespo, Nichole C., Nicosia, Santo V., Hamilton, Andrew D., Sebti, Said M., Cheng, Jin Q.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2000
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85069/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10594016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.1.139-148.2000
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