Large T-Antigen Double Hexamers Imaged at the Simian Virus 40 Origin of Replication

The initial step of simian virus 40 (SV40) DNA replication is the binding of the large tumor antigen (T-Ag) to the SV40 core origin. In the presence of Mg(2+) and ATP, T-Ag forms a double-hexamer complex covering the complete core origin. By using electron microscopy and negative staining, we visual...

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Hauptverfasser: Valle, Mikel, Gruss, Claudia, Halmer, Lothar, Carazo, José M., Donate, Luis Enrique
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
DNA Dynamics and Chromosome Structure
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85037/
https://ncbi.nlm.nih.gov/pubmed/10594006
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