Large T-Antigen Double Hexamers Imaged at the Simian Virus 40 Origin of Replication

The initial step of simian virus 40 (SV40) DNA replication is the binding of the large tumor antigen (T-Ag) to the SV40 core origin. In the presence of Mg(2+) and ATP, T-Ag forms a double-hexamer complex covering the complete core origin. By using electron microscopy and negative staining, we visual...

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Bibliografiske detaljer
Main Authors: Valle, Mikel, Gruss, Claudia, Halmer, Lothar, Carazo, José M., Donate, Luis Enrique
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85037/
https://ncbi.nlm.nih.gov/pubmed/10594006
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