Large T-Antigen Double Hexamers Imaged at the Simian Virus 40 Origin of Replication

The initial step of simian virus 40 (SV40) DNA replication is the binding of the large tumor antigen (T-Ag) to the SV40 core origin. In the presence of Mg(2+) and ATP, T-Ag forms a double-hexamer complex covering the complete core origin. By using electron microscopy and negative staining, we visual...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Valle, Mikel, Gruss, Claudia, Halmer, Lothar, Carazo, José M., Donate, Luis Enrique
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2000
Materias:	DNA Dynamics and Chromosome Structure
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10594006/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.1.34-41.2000
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