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NOD Mice Are Defective in Proteasome Production and Activation of NF-κB

The nonobese diabetic (NOD) mouse is an animal model of human type I diabetes with a strong genetic component that maps to the major histocompatibility complex (MHC) of the genome. We have identified in NOD lymphocytes a specific proteasome defect that results from the lack of the LMP2 subunit. The...

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Pubblicato in:Mol Cell Biol
Autori principali: Hayashi, Takuma, Faustman, Denise
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1999
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85003/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10567588/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.12.8646
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