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NOD Mice Are Defective in Proteasome Production and Activation of NF-κB

The nonobese diabetic (NOD) mouse is an animal model of human type I diabetes with a strong genetic component that maps to the major histocompatibility complex (MHC) of the genome. We have identified in NOD lymphocytes a specific proteasome defect that results from the lack of the LMP2 subunit. The...

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Bibliografische gegevens
Hoofdauteurs: Hayashi, Takuma, Faustman, Denise
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85003/
https://ncbi.nlm.nih.gov/pubmed/10567588
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